Liquid Biopsy: Promises and Problems

Biopsies have been an integral part of cancer care for decades. In undiagnosed patients, oncologists can examine suspicious tissues and determine if the cells are benign or malignant. Following diagnosis, biopsies can reveal additional information about a patient’s tumor – What mutations are driving this cancer? Is this patient likely to respond to a particular therapy? In cases of cancer recurrence, biopsies can provide further information – Has this patient become resistant to treatment? Is the tumor driven by different mutations?

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DNA Profiling Moves From Forensics to Diagnostics

Television series like CSI: Crime Scene Investigation familiarized viewers with advances in forensic science that allow investigators to detect minute amounts of a person’s unique DNA sequence found at a crime scene and analyze it to implicate or exonerate a suspect. Similar DNA technologies can also detect and analyze small numbers of cancer cells in blood.

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AACR Team Science Awardees Devise a Method to Detect Common Cancers Early

Early detection of cancer is arguably a holy grail in the field of cancer research. Catching the disease at an early stage could ultimately prevent thousands of deaths from late-diagnosed disease, which is more challenging to treat. Early detection tests exist for a handful of individual cancers, but no approved method can simultaneously screen for multiple types of cancer.

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Biomarkers and Liquid Biopsy for Early Detection of Colorectal Cancer

AACR is the proud Scientific Partner for Stand Up To Cancer (SU2C), and for Colorectal Cancer Awareness Month, we asked the co-leader of the SU2C–Dutch Cancer Society Dream Team on Molecular Early Detection of Colorectal Cancer, Victor Velculescu, MD, PhD, about the work of the Dream Team and other efforts in this field of cancer research.

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