AACR Annual Meeting 2019: Preclinical Steps Toward a Cancer Preventive Vaccine for Lynch Syndrome

Cancer prevention refers to measures that people can take to reduce their risk of developing cancer. These measures can include lifestyle changes, like eliminating tobacco use, maintaining a healthy weight, staying active, and limiting exposure of skin to ultraviolet light. As our scientific knowledge of cancer etiology and the biology of premaligancy has grown, so too has our ability to rationally develop targeted and immunotherapeutic interventions for cancer prevention, in particular for those who inherit genetic mutations that predispose them to developing cancer.

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Recent Advances in Colorectal Cancer Research

Colorectal cancer is the second leading cause of cancer death in the United States. More than 50,000 people are estimated to have died from colorectal cancer in the United States last year, according to federal statistics.

Colorectal cancer typically begins as a slow-growing, noncancerous polyp which, over time, can progress to invasive cancer. If a cancerous polyp isn’t removed, it can penetrate the lining of the large intestine, allowing the cancer to spread to other organs through blood or lymph vessels. With screening, it is possible to detect and remove polyps before they become cancerous. An increase in colorectal cancer awareness and screening has most likely contributed to the overall reduction in colorectal cancer incidence in the last 30 years.

As March is Colorectal Cancer Awareness Month, we’ve put together a selection of recent colorectal cancer studies across the AACR portfolio along with screening recommendations and risk factors associated with this disease.

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Biomarkers and Liquid Biopsy for Early Detection of Colorectal Cancer

AACR is the proud Scientific Partner for Stand Up To Cancer (SU2C), and for Colorectal Cancer Awareness Month, we asked the co-leader of the SU2C–Dutch Cancer Society Dream Team on Molecular Early Detection of Colorectal Cancer, Victor Velculescu, MD, PhD, about the work of the Dream Team and other efforts in this field of cancer research.

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The Cost of Cancer Disparities

The AACR’s disparities conference covered a wide array of issues this year, from the biological factors that make some racial and ethnic groups especially prone to certain types of cancer, to intriguing new ways to improve prevention and detection, to the cost of cancer disparities.

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Q&A With Raymond DuBois, MD, PhD, on Colorectal Cancer Prevention and Treatment

Raymond DuBois, MD, PhD, past-president of the AACR (2008-2009), fellow of the AACR Academy, and chairman and president of the AACR Foundation, discusses current colorectal cancer screening guidelines, treatment options, and disparities.

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