One of the most watched areas in the immuno-oncology field is the development of chimeric antigen receptor (CAR) T-cell therapy. Carl June, MD, professor in immunotherapy at the Perelman School of Medicine at the University of Pennsylvania, is a pioneer in the CAR T field; he helped to treat the first child with CAR T-cell therapy, which was experimental at the time. Emily Whitehead, who was treated with CAR T cells in 2012 for acute lymphoblastic leukemia after she relapsed twice following treatment with chemotherapy, remains in complete remission today.Read More
In the 1970s television series The Six Million Dollar Man, the narrator says of severely injured astronaut Steve Austin: “We can rebuild him. We have the technology. We can make him better than he was. Better, stronger, faster.” The narrator was referring to “bionic” technologies that provided higher visual acuity, stunning strength, and the ability to run at speeds greater than 60 miles per hour.
Over the past few years, cancer immunologists have achieved a comparable feat. They have taken T cells—the immune cells capable of destroying infectious agents, foreign cells, and cancers—and rebuilt them to be better than they were, better at recognizing and killing cancer cells.Read More
Earlier this week, the U.S. Food and Drug Administration (FDA) approved expanding the use of the immunotherapeutic tisagenlecleucel (Kymriah) to include certain patients with non-Hodgkin lymphoma.
In August 2017, tisagenlecleucel became …
A study presented at the AACR Annual Meeting 2018 discussed preliminary data on an off-the-shelf, T-cell receptor (TCR)-less, dual-targeted CD19-CAR T-cell product, FT819. In proof-of-concept preclinical studies, FT819 was found …Read More
A study presented in the AACR Annual Meeting 2018 Media Preview webinar, held March 15, examined closely a key ingredient necessary to make effective chimeric antigen receptor (CAR) T cells – the T cells of a patient. The researchers behind this study have identified one potential reason for why we have not been successful in making CAR T-cell therapy work against solid tumors, and offer a solution.Read More
Last week, the U.S. Food and Drug Administration (FDA) approved the second of a revolutionary new type of immunotherapy known as chimeric antigen receptor (CAR) T–cell therapy.Read More