From the Journals: Editors’ Picks for November

Each month, the editors from the portfolio of scientific journals published by the American Association for Cancer Research (AACR) highlight one “must read” article from every journal issue, which we summarize here. This month’s edition is stuffed with studies relating to recent clinical trials, a preclinical investigation of NSAIDs for the inhibition of colon tumor progression, and many more. As always, articles featured here are freely available for a limited time.

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Can Distress Screening Help Caregivers?

November is National Family Caregivers Month—a time to raise awareness for the approximately 3 million people in the U.S. who act as caregivers to their relatives, friends, or partners—all while juggling other demanding roles in life.

An article appearing in the fall issue of Cancer Today, a resource for cancer patients, survivors, and caregivers, highlights efforts to understand the nature of distress in caregiving and better ways to provide support for those who need it.

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New AACR-Novocure Funding Initiatives Support Tumor Treating Fields Research

Earlier this year, the American Association of Cancer Research (AACR) partnered with Novocure, a global oncology company, to launch several new funding initiatives to support innovative research focused on Tumor Treating Fields (TTFields). TTFields is a novel noninvasive cancer therapy approved by the U.S. Food and Drug Administration for the treatment of adults with glioblastoma multiforme (GBM) and malignant pleural mesothelioma (MPM). Patients wear a portable electric field generator that delivers TTFields to tumors via electrodes attached to the skin over the tumor site.

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Value-Based Cancer Care: Paying for Performance

The Centers for Medicare & Medicaid Services offers value-based programs that “reward health care providers with incentive payments for the quality of care they give to people.” Many private insurers offer similar payment approaches or are considering how to do so. The hope is that financial rewards will go to physicians, hospitals and health systems that deliver the best patient outcomes, not simply generate the largest number of procedures, laboratory tests, radiographic images, and drugs.

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Targets Conference Showcases Exciting Data from Clinical Trials of Innovative Cancer Therapeutics

There has been an explosion in the number of cancer therapeutics and clinical trials in the recent past, owing to our ability to better define the molecular targets of different cancers using cutting-edge technologies. Unlike in the past, data from early-stage clinical trials are getting more attention lately because the efficacy of a therapeutic, traditionally evaluated in later-phase trials, is often becoming evident earlier in the course of clinical testing.

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Ovarian Cancer: Examining the Microenvironment and Mutational Landscapes to Tailor Treatments

The AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held this year at the Hynes Convention Center in Boston Oct. 26-30, has once again brought together members of academia, pharmaceutical industry, federal regulatory agencies, and all other stakeholders in the cancer drug development space from across the globe to discuss the most up-to-date advances.

A couple of studies presented at the conference set out to address an important question in cancer research – why is ovarian cancer so hard to treat?

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ESPN Reporter Holly Rowe Works Through Cancer

Sports are often referred to as a metaphor for life. But, for ESPN reporter Holly Rowe, sports are quite literally a way of life. When Rowe was undergoing treatment for desmoplastic melanoma, her passion for sports—and telling athletes’ stories from the sidelines—helped her muscle through her own personal struggles.

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AACR Meeting Highlights Recent Advances in Pediatric Cancer Research

Pediatric cancer, while rare, is a devastating diagnosis that is estimated to affect over 11,000 children in the United States in 2019. Among those diagnosed between birth and age 14, more than 1,000 are anticipated to die from the disease this year. The most common types of cancer in this age group are leukemias, brain and other central nervous system (CNS) tumors, and lymphomas.

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Toward Achieving Health Equity – A Preview of the 12th AACR Cancer Health Disparities Conference

In recent decades, the cancer research community has made great strides by bringing new, targeted, safer, and longer-lasting treatments to patients dealing with a variety of cancers. While this achievement is truly remarkable and laudable, a glaring fact is that these groundbreaking advances have not translated into progress for everyone.

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