AACR Annual Meeting 2019: Manipulating the Immune System in Cancer Therapy

Cancer immunotherapy research has exploded in recent years. This treatment utilizes a patient’s own immune system to recognize and attack cancer cells. While many successful immunotherapeutic regimens have relied on checkpoint inhibition, other immunotherapeutic approaches, such as adoptive cellular therapies (ACT), the use of bispecific antibodies, and targeting components of the tumor microenvironment, are showing promise in a variety of cancer types.

Read More

AACR Annual Meeting 2019: Promising Data from CAR T-cell Clinical Trials for Advanced Solid Tumors

A pair of studies presented at the AACR Annual Meeting 2019 demonstrated encouraging clinical outcomes with two different chimeric antigen receptor (CAR) T-cell therapies for patients with advanced solid tumors.

CAR T-cell therapy is a type of immunotherapy in which T cells are removed from a patient’s body and genetically modified so that they can recognize the patient’s cancer cells. The modified T cells, when reintroduced into the patient’s body, multiply and attack cancer cells. The U.S. Food and Drug Administration has approved two CAR T-cell therapies for blood cancers so far: tisagenlecleucel (Kymriah) for treating certain patients with acute lymphoblastic leukemia or non-Hodgkin lymphoma (NHL), and axicabtagene ciloleucel (Yescarta) for treating certain adults with NHL.

Read More

AACR Annual Meeting 2019: Plenary Examines Global Issues in Cancer

The AACR Annual Meeting 2019 features the theme “Integrative Cancer Science • Global Impact • Individualized Patient Care.” That theme provided the structure for Monday’s plenary session, when cancer researchers representing three continents, four cancer types, and diverse areas of interest took the stage.

Read More

AACR Annual Meeting 2019: Preclinical Steps Toward a Cancer Preventive Vaccine for Lynch Syndrome

Cancer prevention refers to measures that people can take to reduce their risk of developing cancer. These measures can include lifestyle changes, like eliminating tobacco use, maintaining a healthy weight, staying active, and limiting exposure of skin to ultraviolet light. As our scientific knowledge of cancer etiology and the biology of premaligancy has grown, so too has our ability to rationally develop targeted and immunotherapeutic interventions for cancer prevention, in particular for those who inherit genetic mutations that predispose them to developing cancer.

Read More

AACR Annual Meeting 2019 Opening Plenary Session: Wearable Technologies, Precision Medicine, and Immunotherapy

The spectacular sight of the AACR Annual Meeting 2019 Opening Ceremony, held Sunday, March 31, at the Georgia World Congress Center in Atlanta was immediately followed by a splendid opening plenary session, titled “Achieving Equitable Patient Care through Precision and Convergent Cancer Science.”

Read More

Recent Advances in Colorectal Cancer Research

Colorectal cancer is the second leading cause of cancer death in the United States. More than 50,000 people are estimated to have died from colorectal cancer in the United States last year, according to federal statistics.

Colorectal cancer typically begins as a slow-growing, noncancerous polyp which, over time, can progress to invasive cancer. If a cancerous polyp isn’t removed, it can penetrate the lining of the large intestine, allowing the cancer to spread to other organs through blood or lymph vessels. With screening, it is possible to detect and remove polyps before they become cancerous. An increase in colorectal cancer awareness and screening has most likely contributed to the overall reduction in colorectal cancer incidence in the last 30 years.

As March is Colorectal Cancer Awareness Month, we’ve put together a selection of recent colorectal cancer studies across the AACR portfolio along with screening recommendations and risk factors associated with this disease.

Read More

Behind the Scenes at the Annual Meeting: Five Questions With the AACR’s Senior Director of Meetings

In just over a month, the Georgia World Congress Center in Atlanta will host the American Association for Cancer Research (AACR) Annual Meeting 2019. This signature event showcases the latest and most promising developments in cancer research, drawing scientists, clinicians, advocates, and policymakers from around the world.

Read More

How Can We Use Technology to Advance Population Science Research?

There has been a rapid expansion of technology in recent years, from artificial intelligence to intensive genetic sequencing to wearable trackers of fitness and health. How all of this technology can be effectively incorporated into population sciences research is an area of active inquiry.

To facilitate discussion and showcase research in this area, the American Association for Cancer Research (AACR) is hosting a conference, Modernizing Population Sciences in the Digital Age, in San Diego from Feb. 19-22. This four-day meeting will include discussions about the best use of mobile technology, how to best leverage large datasets, and how to incorporate modern technologies into existing and upcoming studies.

Read More

Meet John D. Carpten, PhD, Program Chair of the AACR Annual Meeting 2019

The American Association for Cancer Research (AACR) Annual Meeting 2019 will soon be upon us. It begins in the Georgia World Congress Center, Atlanta, at 3 p.m. on Friday, March 29. The Friday start, which is a day earlier than usual, is to ensure that meeting attendees have the maximal ability to participate in the expanded slate of educational sessions and methods workshops included in this year’s program. The content of these and the other AACR Annual Meeting 2019 sessions can be viewed through the Online Itinerary Planner starting later today.

Read More