AACR Journals Editors’ Picks for February

As a regular post on this blog, we feature the 10 articles chosen by our editors from all journal issues published each month by the American Association of Cancer Research (AACR). For February, these articles span from a review of recent preclinical studies focused on brain metastases to a first-in-human immunotherapy trial. As always, articles highlighted here are freely available for a limited time.

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From the Journals: Editors’ Picks for January

Back for the new year, here are the editors’ selections for the January issues of the eight scientific journals published by the American Association for Cancer Research (AACR). Featured research highlights a wide variety of cancer-related topics, spanning from preclinical therapeutic strategies to cancer prevention. All articles summarized here are freely available for a limited time.

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December Editors’ Picks from AACR Journals

The staff of Cancer Research Catalyst was pleased to introduce a new feature this year: Editors’ Picks, a monthly collection of articles selected by the editors of the eight scientific journals published by the American Association for Cancer Research (AACR). To wrap up the year, here are the editors’ choices for December. As always, these articles are freely available for a limited time.

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AACR Journals Editors’ Picks for November

Every month, the editors from the eight scientific journals published by the American Association for Cancer Research (AACR) select one “must read” article from each issue. Highlighted research encompasses a wide variety of cancer-related discoveries, including basic scientific investigation and epidemiological studies. Read on to learn about this month’s selections, which are freely accessible for a limited time.

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Can Artificial Intelligence Help Reduce False-positive Mammograms?

In a study published in the AACR’s journal Clinical Cancer Research, a team of scientists from the University of Pittsburgh discuss yet another area of cancer research where artificial intelligence (AI) can potentially solve a decades-long problem: false-positive results and high patient recall rates from breast cancer screening mammography.

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Harnessing the Power of Precision Medicine – Treating Cancers with Tissue-agnostic Therapies

Cancer treatments have been, and continue to be in most cases, based on the organ site where the tumor originates—some treatments are specific for breast cancer, some for lung cancer, and so on. However, rapid advances in genomic sequencing technologies have led to a recent development that deviates from the long-held notion of treating cancers based on the site of origin.

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A New Device to Monitor Heart Dysfunction in Childhood Cancer Survivors

Anthracyclines, a widely used class of chemotherapeutics, work in several ways to kill rapidly dividing cells, including those found in a tumor. While these drugs are commonly used to treat many types of adult and childhood cancer, they have a detrimental side effect – cardiotoxicity.

The cardiotoxicity of anthracyclines is dose-dependent; the more exposure patients have to the drug, the more serious risk they carry for heart-related problems. This can represent a unique challenge in children treated with anthracyclines, whose hearts are still developing.

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Liquid Biopsy: Promises and Problems

Biopsies have been an integral part of cancer care for decades. In undiagnosed patients, oncologists can examine suspicious tissues and determine if the cells are benign or malignant. Following diagnosis, biopsies can reveal additional information about a patient’s tumor – What mutations are driving this cancer? Is this patient likely to respond to a particular therapy? In cases of cancer recurrence, biopsies can provide further information – Has this patient become resistant to treatment? Is the tumor driven by different mutations?

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