July Editors’ Picks from AACR Journals

As a monthly staple on this blog, we feature the editors’ picks from the 10 journal issues published by the American Association for Cancer Research (AACR). This month, selections include two articles detailing laboratory culture methods to model human cancers, as well as results from two clinical trials, among other studies. Per usual, articles summarized here are freely available for a limited time.

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June Editors’ Picks from AACR Journals

Back for the month of June are the editors’ picks from the eight scientific journals published by the American Association for Cancer Research (AACR). Selections this month range from the identification of a long noncoding RNA involved in the canonical TGFβ/Smad signaling pathway to results from a clinical trial for patients with neuroendocrine tumors, a rare cancer type. Articles highlighted below are freely available for a limited time.

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From the Journals: Editors’ Picks

As a regular feature on this blog, we spotlight 10 “must read” articles selected by our editors from each journal issue published by the American Association for Cancer Research (AACR). For the month of April, articles span from a preclinical study of a selective HER-2 inhibitor to a report on the prevalence of cancer risk factors and screening rates in the United States. As always, all articles summarized here are freely available for a limited time.

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AACR Annual Meeting 2019: Manipulating the Immune System in Cancer Therapy

Cancer immunotherapy research has exploded in recent years. This treatment utilizes a patient’s own immune system to recognize and attack cancer cells. While many successful immunotherapeutic regimens have relied on checkpoint inhibition, other immunotherapeutic approaches, such as adoptive cellular therapies (ACT), the use of bispecific antibodies, and targeting components of the tumor microenvironment, are showing promise in a variety of cancer types.

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March Editors’ Picks from AACR Journals

Back for March are the editors’ picks from the portfolio of scientific journals published by the American Association for Cancer Research (AACR). This month, articles include results from two clinical trials, two preclinical pancreatic cancer studies, and more. As always, articles summarized here are freely available for a limited time.

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Prostate Cancer Disparities: Race-related Biological Differences

Non-Hispanic black men in the United States are much more likely to develop prostate cancer and to die from the disease than their non-Hispanic white counterparts. Many factors contribute to this striking disparity, including access to and use of health care, social and economic status, and biology. As discussed by Steven R. Patierno, PhD, and colleagues in a recent perspective article in the AACR journal Clinical Cancer Research, alternative RNA splicing is one biological factor contributing to prostate cancer disparities.

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Recent Advances in Colorectal Cancer Research

Colorectal cancer is the second leading cause of cancer death in the United States. More than 50,000 people are estimated to have died from colorectal cancer in the United States last year, according to federal statistics.

Colorectal cancer typically begins as a slow-growing, noncancerous polyp which, over time, can progress to invasive cancer. If a cancerous polyp isn’t removed, it can penetrate the lining of the large intestine, allowing the cancer to spread to other organs through blood or lymph vessels. With screening, it is possible to detect and remove polyps before they become cancerous. An increase in colorectal cancer awareness and screening has most likely contributed to the overall reduction in colorectal cancer incidence in the last 30 years.

As March is Colorectal Cancer Awareness Month, we’ve put together a selection of recent colorectal cancer studies across the AACR portfolio along with screening recommendations and risk factors associated with this disease.

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Hyperglycemia and Aggressive Prostate Cancer Risk

Rates of diabetes in the United States are increasing. According to statistics from the Centers for Disease Control and Prevention (CDC), an estimated 23 million Americans received a diagnosis of diabetes in 2015, in contrast to 1.6 million Americans in 1958. Our risk for diabetes increases as we age; over 25 percent of those ages 65 or older had diabetes in 2015, according to the CDC.

Diabetes is a risk factor for several types of cancer, including liver, pancreatic, and endometrial cancers. While this association is complex, some possible biological links include insulin resistance and hyperglycemia.

Previous work to understand the relationship between hyperglycemia and prostate cancer risk and mortality have yielded mixed results. A recent study published in Cancer Prevention Research evaluated whether hyperglycemia, as measured through multiple biomarkers, is associated with prostate cancer incidence and mortality.

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