AACR Cancer Progress Report 2019: Harnessing Research Discoveries for Patient Benefit

Today, the American Association for Cancer Research (AACR) released its ninth annual Cancer Progress Report. The report highlights how research largely supported by federal investments in the National Institutes of Health (NIH) is spurring improvements in public health and innovative breakthroughs across the spectrum of cancer care.

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The Right Dose: Researching Cancer Treatment De-Escalation

Cancer researchers often focus on developing novel treatments or combining therapies in new ways, all with the goal of lengthening survival for patients. But some cancer research has a different goal: to reduce the amount and intensity of treatment patients receive while maintaining equally good cancer outcomes. In the summer 2019 issue of Cancer Today, digital editor Kate Yandell writes about the challenges and successes of this approach, called treatment de-escalation.

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Recent Studies Tap Into AACR Project GENIE Registry

The AACR Project Genomics Evidence Neoplasia Information Exchange (AACR Project GENIE) is a unique registry that aggregates, harmonizes, and links clinical-grade cancer genomic data with clinical outcomes from tens of thousands of cancer patients. AACR Project GENIE recently released its sixth data set, increasing the database to nearly 70,000 de-identified genomic records. The database now has information spanning more than 80 major cancer types, including data from more than 11,000 patients with lung cancer, over 9,700 patients with breast cancer, and nearly 7,000 patients with colorectal cancer.

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Integrative Molecular Epidemiology Unites Cancer Research Disciplines

Cancer is very complex, and the tools that we need to understand how it develops and progresses come from many different scientific fields. Integrative Molecular Epidemiology, known as IME, brings together epidemiologists, data scientists, and basic scientists, along with many clinical specialties, to jointly study cancer from different angles. By its very nature, IME is a truly transdisciplinary field that unites researchers from varied backgrounds. The American Association for Cancer Research (AACR) supports this field through a longstanding working group.

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FDA-AACR Workshop Examines the Practice and Promise of Real-world Evidence in Oncology

Building on advances in technology and analytical tools, real-world data (RWD) sources have attracted increasing interest as means to efficiently answer important clinical, research, and regulatory questions around oncology treatments and outcomes. RWD can come from a variety of sources, including medical claims data, electronic health records, patient-reported outcomes, and product or disease registry data. Real-world evidence (RWE) is clinical evidence generated from these data.

While the randomized controlled trial remains the gold standard for gathering clinical evidence for regulatory use, RWE can provide critical insights in situations where such trials may be difficult to complete. This is especially relevant in oncology, where personalized medicine approaches are leading to increasingly smaller patient populations that necessitate new strategies for efficient drug development.

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Let’s End HPV-related Cancers: A Congressional Briefing

Every two minutes, a woman somewhere in the world dies of cervical cancer.

That harrowing statistic, shared by Anna R. Giuliano, PhD, founding director of the Center for Immunization and Infection Research in Cancer at the Moffitt Cancer Center in Tampa, Florida, reflects a great frustration in public health. There is a vaccine that prevents infection with the virus that can cause cervical cancer and several other cancer types, yet worldwide, not enough people are taking advantage of it.

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Cancer Today Highlights Lessons in Survivorship

Every person who hears the words “you have cancer” has a unique story. As part of Cancer Today’s mission to provide “practical hope” and “real knowledge” to those who are affected by cancer, we strive to highlight those stories to provide a real-life glimpse into the challenges of treatment and what comes after.

As National Cancer Survivor Month comes to a close, we’d like to take an opportunity to reflect on some of the lessons we’ve learned from the cancer survivors who have shared their stories with Cancer Today, the magazine and online resource for cancer patients, survivors, and caregivers, which is published by the American Association for Cancer Research.

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June Editors’ Picks from AACR Journals

Back for the month of June are the editors’ picks from the eight scientific journals published by the American Association for Cancer Research (AACR). Selections this month range from the identification of a long noncoding RNA involved in the canonical TGFβ/Smad signaling pathway to results from a clinical trial for patients with neuroendocrine tumors, a rare cancer type. Articles highlighted below are freely available for a limited time.

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AACR Takes Action Against the “Epidemic” of Youth E-cigarette Use

In the past year, the number of American teenagers using tobacco products has increased by nearly 40 percent, reversing a trend that public health officials worked tirelessly to achieve.
The primary culprit in the resurgence of smoking? E-cigarettes. Taking aim at this growing public health problem, the American Association for Cancer Research (AACR) held a congressional briefing on Wednesday, June 12, titled “E-cigarettes and Nicotine Addiction: A Potential Health Crisis for Youth and Young Adults.” The roster of speakers included leaders from government, research, and policy sectors.

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