Harnessing the Power of Precision Medicine – Treating Cancers with Tissue-agnostic Therapies

Cancer treatments have been, and continue to be in most cases, based on the organ site where the tumor originates—some treatments are specific for breast cancer, some for lung cancer, and so on. However, rapid advances in genomic sequencing technologies have led to a recent development that deviates from the long-held notion of treating cancers based on the site of origin.

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AACR Cancer Progress Report 2018: Harnessing Research Discoveries for Patient Benefit

Today, the American Association for Cancer Research (AACR) released its eighth annual Cancer Progress Report. The report highlights how federally funded research that provides a deep understanding of the complexities of cancer is spurring advances across the clinical cancer care continuum and improving survival and quality of life for people around the world.

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AACR Announces the Global Scholar-in-Training Awards

Building upon the success of the African Cancer Researchers Travel Awards, the American Association for Cancer Research is pleased to announce the expansion of this award program and to invite eligible applicants from all low-, lower-middle, and middle-income economy countries (LMIC).

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The Soil for the Seeds: Investigating the Microenvironment of Acute Myeloid Leukemia

As a predoctoral student in the Integrated Biomedical Sciences Graduate Program at The Ohio State University in 2005, Bethany Mundy-Bosse, PhD, had plans to focus her graduate work on basic stem cell biology to enhance and expand her previous research experience in this field. “When I first started working in a research lab, I was working with stem cells,” recalls Mundy-Bosse, “with every intention of continuing on with basic stem cell biology.” However, after attending a course in immunology with renowned physician-scientist Michael Caligiuri, MD, she found herself completely fascinated by this field. It was this course that would ultimately motivate her to shift her career focus toward tumor immunology.

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FDA Workshop to Address Need for Non-clinical Models to Advance Immuno-oncology

Immuno-oncology has revolutionized treatment for certain types of cancers, but currently it is only effective for about 20 percent of cancer patients. To drive the development of safe and effective immunotherapies for all patients, we need strong science at every stage of drug development, particularly in combination therapy. To this end, refining existing non-clinical models or developing new ones to assess the safety of immuno-oncology products will require cross-sector collaboration among regulatory, industry, and academic experts. The upcoming FDA-AACR Non-clinical Models for Safety Assessment of Immuno-oncology Products Workshop will bring these stakeholders together to discuss this vital issue.

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AACR Project GENIE: More Data, More Participants, and More Progress

AACR Project Genomics Evidence Neoplasia Information Exchange (GENIE) recently hit another milestone: the public release of a fourth dataset, which comes on the heels of three prior public data releases, an expansion of the number of participating institutions, and a recent publication, which was among the most read articles in JCO Clinical Cancer Informatics in July, according to the publisher.

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A New Device to Monitor Heart Dysfunction in Childhood Cancer Survivors

Anthracyclines, a widely used class of chemotherapeutics, work in several ways to kill rapidly dividing cells, including those found in a tumor. While these drugs are commonly used to treat many types of adult and childhood cancer, they have a detrimental side effect – cardiotoxicity.

The cardiotoxicity of anthracyclines is dose-dependent; the more exposure patients have to the drug, the more serious risk they carry for heart-related problems. This can represent a unique challenge in children treated with anthracyclines, whose hearts are still developing.

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AACR Travel Awards Bring African Researchers to Annual Meeting

This past April, the American Association for Cancer Research welcomed its 2018 class of African Cancer Researchers Travel Award (ACRTA) recipients to its Annual Meeting. Established in 2016, these travel awards provide financial assistance to meritorious early-career investigators engaged in cancer research in Africa, allowing them to attend and present their research at the AACR Annual Meeting.

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From the Journals: Editors’ Picks for July

Each month, the American Association for Cancer Research (AACR) publishes 10 articles from its eight esteemed scientific journals, showcasing some of the leading discoveries in cancer research. Read on to learn about the editors’ selections from this month. All articles featured are freely available for a limited time.

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