Lessons Learned From Combining Anti-OX40 and Anti-PD1 Immunotherapies

A pair of studies published recently in journals of the American Association for Cancer Research bring to our attention the unexpected negative consequences of combining two immunotherapeutics concurrently, and discuss the mechanisms behind improved antitumor effects and survival outcomes with sequential administration of the two drugs.

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Catching Childhood Cancers Early: Insights Into the AACR Childhood Cancer Predisposition Workshop

There is perhaps nothing more painful for parents than receiving a cancer diagnosis for their child. Childhood cancers are generally rare, and in the United States, the death rates have …

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Assessing Cancer Patients’ Tobacco Use: A New Tool Developed by the AACR and the National Cancer Institute

Researchers have well established that smoking leads to adverse outcomes in cancer patients; however, the specific effects caused by smoking and the use of other tobacco products remain poorly understood …

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Overcoming Drug Resistance: The EGFR Enigma

Currently, anti-EGFR therapies are approved by the U.S. Food and Drug Administration for the treatment of non-small cell lung cancer, squamous cell carcinoma of the head and neck, pancreatic cancer, and colorectal cancer. Most patients receiving anti-EGFR therapies benefit from the treatment, but the challenge they face, as do patients receiving most other targeted therapies, is that their tumors ultimately develop drug resistance. So efforts are underway to develop newer anti-EGFR therapies that can circumvent resistance to existing EGFR inhibitors.

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Eric Rubin, MD, Discusses How the AACR Contributes to Advances for Patients

AACR membership includes scientists and physicians from across the cancer research enterprise. Whether basic, translational, or clinical researchers, they all share the same goal: to make progress for patients. In this post, Eric Rubin, MD, deputy editor of Clinical Cancer Research, one of the AACR’s eight journals, shares his thoughts on the AACR’s role in developing breakthrough cancer treatments.

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