Srivani Ravoori, PhD

Srivani Ravoori, PhD, is associate director of science communications at the AACR. Ravoori helps manage science content creation for the Communications and Public Relations Department and guides the team in identifying the latest advances in cancer research from the organization's conferences, journals, and other scientific activities. Ravoori helps develop strategies to integrate and streamline the dissemination of cancer science through various communications and social media platforms. Ravoori is an experienced science content developer and an expert in translating complex cancer science into simple language with the goal of educating the public, media, policymakers, and the health care industry about the importance of cancer research. She holds a PhD degree in cancer biology and dedicated the first 15 years of her career to conducting basic and translational cancer research.

Learning From the Immune System of Long-term Pancreatic Cancer Survivors

November is pancreatic cancer awareness month.

A look at the statistics from the SEER database is a stark reminder that pancreatic cancer is a deadly disease with a five-year survival rate of a mere 8.2 percent. Unfortunately, the last 30 years has not seen any significant improvement in survival for patients with this disease. Pancreatic cancer is projected to become the second leading cause of deaths due to cancer in the United States by 2030.

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Treating DNA Repair-deficient Breast Cancers

Several clinical trials are underway in which PARP inhibitors are being tested in breast cancers, mostly triple-negative breast cancers, because they often harbor BRCA mutations and DNA repair deficiencies. Emerging studies show that the benefit of PARP inhibitors could extend beyond breast cancers with germline BRCA mutations.

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Recent Advances in Measuring Response to Immune Checkpoint Inhibitors

In recent years, the U.S. Food and Drug Administration has approved immune checkpoint inhibitors, a class of immunotherapy, to treat 10 different types of cancer, in addition to solid tumors located anywhere in the body that have certain DNA damage and repair-related biomarkers. However, only a small percentage of patients respond to these treatments, and they can have significant side effects. Researchers are looking for biomarkers that can identify patients who are likely to respond to immune checkpoint inhibitors.

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Lessons Learned From Combining Anti-OX40 and Anti-PD1 Immunotherapies

A pair of studies published recently in journals of the American Association for Cancer Research bring to our attention the unexpected negative consequences of combining two immunotherapeutics concurrently, and discuss the mechanisms behind improved antitumor effects and survival outcomes with sequential administration of the two drugs.

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The Fuzzy Factor: Striving to Protect Patient Privacy in Big Data Sets

A major objective of former Vice President Joe Biden’s National Cancer Moonshot Initiative is breaking down silos and sharing cancer patients’ data across centers. This path is critical to bringing new dimensions to understanding the molecular biology of cancer, leading to the rapid identification of new therapeutic targets and accelerated development of molecularly informed cancer therapeutics.

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What Advances are Researchers Making in Treating Glioblastoma, McCain’s Cancer?

As we learned recently, Senator John McCain was diagnosed with glioblastoma multiforme, an aggressive form of central nervous system tumor that starts in the brain or spinal cord. It accounts for about 45 percent of all primary brain tumors, with about 11,000 diagnoses in men, women, and children each year.

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A Targeted Therapy Next in Line for Biomarker-based Cancer Drug Approval?

recent data suggest that there is another potential contender for a biomarker-based FDA approval: a targeted therapeutic called larotrectinib (LOXO-101), which showed promising results in adults and children with a variety of cancer types, all of which had one thing in common – fusions involving the gene TRK.

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Catching Childhood Cancers Early: Insights Into the AACR Childhood Cancer Predisposition Workshop

There is perhaps nothing more painful for parents than receiving a cancer diagnosis for their child. Childhood cancers are generally rare, and in the United States, the death rates have …

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Advancing Translational Cancer Medicine in Latin America

In recent years, the American Association for Cancer Research (AACR) has expanded its efforts to catalyze advances in cancer research globally and support its members residing in 107 countries in addition to the United States. One important initiative this year was the landmark conference held May 4-6, in São Paulo, Brazil—the AACR International Conference on Translational Cancer Medicine.

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Do Genomic Approaches to Selecting Cancer Treatment Yield Better Patient Outcomes Than Traditional Approaches?

A study published recently in the AACR’s journal Cancer Discovery addresses the burgeoning question of the utility of high-throughput genomic analysis in identifying targeted therapies and delivering better outcomes for cancer patients, and adds important evidence to argue in favor of such an approach. The jury, nevertheless, is still out.

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