Srivani Ravoori, PhD

Srivani Ravoori, PhD, is associate director of science communications at the AACR. Ravoori helps manage science content creation for the Communications and Public Relations Department and guides the team in identifying the latest advances in cancer research from the organization's conferences, journals, and other scientific activities. Ravoori helps develop strategies to integrate and streamline the dissemination of cancer science through various communications and social media platforms. Ravoori is an experienced science content developer and an expert in translating complex cancer science into simple language with the goal of educating the public, media, policymakers, and the health care industry about the importance of cancer research. She holds a PhD degree in cancer biology and dedicated the first 15 years of her career to conducting basic and translational cancer research.

AACR Annual Meeting 2018: Off-the-shelf CAR T-cell Immunotherapy – Are we There Yet?

A study presented at the AACR Annual Meeting 2018 discussed preliminary data on an off-the-shelf, T-cell receptor (TCR)-less, dual-targeted CD19-CAR T-cell product, FT819. In proof-of-concept preclinical studies, FT819 was found …

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Improving the Effectiveness of CAR T-cell Immunotherapy

A study presented in the AACR Annual Meeting 2018 Media Preview webinar, held March 15, examined closely a key ingredient necessary to make effective chimeric antigen receptor (CAR) T cells – the T cells of a patient. The researchers behind this study have identified one potential reason for why we have not been successful in making CAR T-cell therapy work against solid tumors, and offer a solution.

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Experts Forecast Cancer Research and Treatment Advances in 2018

This past year has been a year of many “firsts” for the oncology community, with several revolutionary advances in the research and treatment of cancer, We asked experts in the fields of immunotherapy, precision medicine, and prevention and disparities research where the cancer research community is headed next and what major accomplishments we might expect in 2018 to take us closer to conquering cancer.

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Learning From the Immune System of Long-term Pancreatic Cancer Survivors

Pancreatic cancer is a deadly disease with a five-year survival rate of a mere 8.2 percent, according to statistics from the SEER database. Unfortunately, the last 30 years has not seen any significant improvement in survival for patients with this disease. Pancreatic cancer is projected to become the second leading cause of deaths due to cancer in the United States by 2030.

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Treating DNA Repair-deficient Breast Cancers

Several clinical trials are underway in which PARP inhibitors are being tested in breast cancers, mostly triple-negative breast cancers, because they often harbor BRCA mutations and DNA repair deficiencies. Emerging studies show that the benefit of PARP inhibitors could extend beyond breast cancers with germline BRCA mutations.

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Recent Advances in Measuring Response to Immune Checkpoint Inhibitors

In recent years, the U.S. Food and Drug Administration has approved immune checkpoint inhibitors, a class of immunotherapy, to treat 10 different types of cancer, in addition to solid tumors located anywhere in the body that have certain DNA damage and repair-related biomarkers. However, only a small percentage of patients respond to these treatments, and they can have significant side effects. Researchers are looking for biomarkers that can identify patients who are likely to respond to immune checkpoint inhibitors.

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Lessons Learned From Combining Anti-OX40 and Anti-PD1 Immunotherapies

A pair of studies published recently in journals of the American Association for Cancer Research bring to our attention the unexpected negative consequences of combining two immunotherapeutics concurrently, and discuss the mechanisms behind improved antitumor effects and survival outcomes with sequential administration of the two drugs.

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